A1C & Diabetes Treatment Options | Humulin R U-500 (2024)

00:00-00:04

[Humulin logo symbol appears in the center of the screen and opens up to reveal the full logo and text]

Caption: How to use your U-500 KwikPen

Caption: PP-HM-US-2135 ©Lilly USA, LLC 2023. All rights reserved.

00:06-00:10

[A timeline for this video appears, sharing the timestamps for parts of the video]

Narrator: Welcome to a demonstration of Humulin R U-500 KwikPen.

Caption: 0:00

Caption: 1:45 - Preparing your Humulin® R U-500 KwikPen®

Caption: 3:04 - Priming your Humulin R U-500 KwikPen

Caption: 4:18 - Selecting your dose

Caption: 6:19 - Giving your injection

Caption: 8:10 - After your injection

Caption: 8:37 - Disposing of your Pens and needles

Caption: 10:11 - Storing your Pen

Caption: 10:58 - General information

Caption: 13:10 - Important Safety Information

00:16-00:26

[An animation of the Humulin R U-500 KwikPen spinning appears on screen]

Narrator: Humulin® R U-500 is used to treat people with diabetes who need more than 200 units of insulin a day for the control of high blood sugar. Let’s get to know your pen.

Caption: Humulin® R U-500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin a day.

Caption: Humulin R U-500 contains 5 times as much insulin in the same volume (500 units/mL) as Humulin R U-100 (100 units/mL).

00:26-00:34

[The camera zooms in on the Humulin R U-500 KwikPen]

Narrator: Humulin R U-500 KwikPen is a disposable pen. Dial your dose as instructed by your doctor.

Caption: It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins or when used in an insulin pump.

Caption: Refer to the Instructions for Use included with your Pen before you start taking Humulin® R U-500 and each time you get another Pen.

00:34-00:53

[A 2D graphic of the pen and cap appears on screen with text]

Narrator: It's important to know your dose of Humulin R U-500. The Humulin R U-500 KwikPen delivers your dose in insulin units. Insulin units may not be the same as syringe markings. Ask your doctor what your dose should be for your pen.

Caption: IMPORTANT

Caption: Know your dose of Humulin® R U-500 insulin. The Pen delivers your dose in insulin units. Insulin units may not be the same as syringe markings. Ask your doctor what your dose should be for your Pen.

00:53-01:10

[A graphic appears on screen that looks like a KwikPen dose knob shows the number 5 selected]

Narrator: The Humulin R U-500 KwikPen is different from other pens you may have used. It dials 5 insulin units with each click. Do not count clicks of the dose knob to select your dose. You may not get enough insulin, or you may get too much insulin.

Caption: IMPORTANT

Caption: Your Humulin® R U-500 KwikPen® (Pen) works differently from other pens. It dials 5 insulin units with each click. Do not count clicks of the dose knob to select your dose. You may get too much insulin or you may not get enough insulin.

01:10-01:24

[An image appears on screen, showing an arrow pointing from the Humulin R U-500 KwikPen to an image of a syringe, and the arrow is crossed out, indicating to not transfer insulin from the Pen to a syringe.]

Narrator: Humulin R U-500 is a concentrated insulin. Do not transfer Humulin R U-500 insulin from your pen into a syringe. A severe overdose can happen, causing very low blood sugar which may put your life in danger.

Caption: IMPORTANT

Caption: Humulin® R U-500 is a concentrated insulin. DO NOT transfer Humulin R U-500 insulin from your Pen into a syringe. A severe overdose can happen, causing very low blood sugar which may put your life in danger.

Caption: DO NOT TRANSFER TO A SYRINGE SEVERE OVERDOSE CAN RESULT

01:24-01:38

[An image appears on screen with one hand giving the pen to another hand, and both hands and the pen are crossed out, indicating that a pen should not be shared with another person.]

Narrator: Do not share your pen with other people, even if the needle has been changed. Do not reuse or share your needles with other people. You may give an infection to them, or get an infection from them.

Caption: IMPORTANT

Caption: Do not share your Humulin® R U-500 KwikPen® or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

01:38-01:50

[An image of the pen is crossed out, indicating it should not be used by the blind or visually-impaired]

Narrator: This pen is not recommended for use by the blind or visually-impaired, without the help of someone trained to use the pen. Now, let’s get started.

Caption: IMPORTANT

Caption: People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen.

01:51-01:58

Narrator: Step 1. Preparing your Humulin R U-500 KwikPen. You will need the following supplies:

Caption: Step 1: Preparing your Humulin® R U-500 KwikPen®

01:58-2:04

[An image of the Humulin R U-500 KwikPen, the pen needle and an alcohol swab appear on screen]

Narrator: Your pen, compatible pen needle, and an alcohol swab.

Caption: BD Pen Needles Recommended

2:04-2:09

[An image of two hands washing with soap appears on screen]

Narrator: Before you begin, wash your hands with soap and water first.

Caption: Wash your hands with soap and water

2:09-2:30

[An image of the Humulin R U-500 KwikPen appears on screen, with a line pointing to the Insulin type on the label. The pen label expands to show the expiration area on the label]

Narrator: Check the Pen to make sure you are taking the right type of insulin. This is especially important if you use more than 1 type of insulin. And check the expiration date. Do not use your Pen past the expiration date printed on the label, or for more than 28 days after you first start using the Pen.

Caption: Wash your hands with soap and water

Caption: Check the Pen and type of insulin

Caption: Insulin type

Caption: Do not use your Pen past the expiration date printed on the label

Caption: Expiration

2:30-2:48

[An animation shows the cap being removed from the Humulin R U-500 KwikPen, and an alcohol swab wiping the rubber seal on the pen]

Narrator: When you’re ready, pull the Pen cap straight off. Do not remove the Pen label. Wipe the rubber seal with an alcohol swab. The insulin should be clear and colorless. Do not use if it is cloudy, colored, or has particles or clumps in it.

2:48-3:09

[An animation showing a paper tab being removed from a new needle, and the new needle being pushed securely onto the Pen, and the outer needle shield being removed and thrown away.]

Narrator: If everything looks good, select a new needle. Pull off the paper tab from the outer needle shield. Push the capped needle straight onto the Pen and twist the needle until it is tight. Pull off the outer needle shield. Do not throw it away. Pull off the inner needle shield and throw it away.

Caption: Always use a new needle for each injection to help prevent infections and blocked needles.

3:09-3:20

Narrator: Step 2: Priming your Humulin R U-500 KwikPen. It’s important to prime your Pen before each injection

Caption: Step 2: Priming your Humulin® R U-500 KwikPen®

3:20-3:36

[The Humulin R U-500 KwikPen appears on screen]

Narrator: Priming your Pen means removing the air from the needle and cartridge that may collect during normal use and ensures that the Pen is working correctly. If you do not prime before each injection, you may get too much or too little insulin.

Caption: Removes air from the needle and cartridge

Caption: If you do not prime, you may get too much or too little insulin.

3:36-3:50

[An animation of the Humulin R U-500 KwikPen appears on screen, showing the pen dose knob turning to 5 units, holding the pen with the needle pointing up and a hand tapping the pen on the side; The 3D pen disappears to show a 2D graphic of someone tapping a Pen near the needle]

Narrator: To prime your Pen, turn the dose knob to select 5 units. Hold your Pen with the needle pointing up. Then, tap the cartridge holder gently to collect air bubbles at the top.

Caption: Turn the dose knob to select 5 units.

Caption: Hold your Pen with the needle pointing up.

Caption: Tap the cartridge holder gently to collect air bubbles at the top.

3:50-4:24

[An animation of the Humulin R U-500 KwikPen appears on screen, indicating how to hold the pen upright, pushing the dose knob and seeing insulin at the tip of the needle]

Narrator: Continue holding your pen with the needle pointing up. Push the dose knob in until it stops, and zero is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle. If you do not see insulin, repeat the priming steps, but not more than 8 times. If you still do not see insulin, change the needle and repeat the priming steps. Small air bubbles are normal and will not affect your dose.

Caption: If you do not see insulin, repeat the priming steps, but not more than 8 times.

Caption: If you still do not see insulin, change the needle and repeat the priming steps.

4:24-4:27

Narrator: Step 3: Selecting your dose.

Caption: Step 3: Selecting your dose

4:27-5:00

[The Humulin R U-500 KwikPen appears on screen, with a close up of the dose window on the pen.]

Narrator: Humulin R U-500 KwikPen has been designed to deliver the dose in insulin units that is shown in the dose window. Ask your doctor what your dose should be for this Pen. You can give from 5 to 300 units in a single injection. If your dose is more than 300 units, you will need to give more than one injection. If you need help deciding how to divide up your dose, ask your doctor. You must use a new needle for each injection and repeat the priming step.

Caption: Dose window

5:00-5:59

[A 3D up-close animation of the Humulin R U-500 KwikPen appears on screen, with a close up of the dose window moving between higher and lower dose amounts]

Narrator: To select your dose, turn the dose knob to select the number of units you need to inject. The dose indicator should line up with your dose. The dose knob clicks as you turn it. Each click of the dose knob dials 5 units at a time. Do not dial your dose by counting the clicks because you may dial the wrong dose. This may lead to you getting too much insulin or not enough insulin. The dose can be corrected by turning the dose knob in either direction until the correct dose lines up with the dose indicator. The even numbers (for example, 10, 20, 30) are printed on the dial. The odd numbers (for example, 5, 15, 25) are shown as lines between the even numbers. Always check the number in the dose window to make sure you have dialed the correct dose. The Pen will not let you dial more than the number of units left in the Pen.

Caption: 5 units at a time

5:59-6:15

[The Humulin R U-500 KwikPen appears on screen, with a graphic of a hand injecting the pen into their body next to the 3D model of the KwikPen]

Narrator: If your dose is more than the number of units left in the Pen, you may either: Inject the amount left in your Pen and then use a new Pen to give the rest of your dose, or get a new Pen and inject the full dose.

Caption: Inject the amount left in your Pen and then use a new Pen to give the rest of your dose

Caption: OR

Caption: Get a new Pen and inject the full dose.

6:15-6:25

[An arrow pointing from the Humulin R U-500 KwikPen to a syringe is crossed out, indicating to NOT transfer insulin to a syringe.]

Narrator: It is normal to see a small amount of insulin left in the Pen that you cannot inject. Do not transfer this to a syringe. Severe overdose can happen.

6:25-6:29

Narrator: Step 4: Giving your injection.

Caption: Step 4: Giving your injection

6:29-6:43

[The 3D Humulin R U-500 KwikPen appears on screen]

Narrator: You are now ready to inject your insulin as your doctor has shown you. Be sure to change or rotate your injection site for each injection. And do not try to change your dose while injecting.

Caption: Inject as your doctor has shown you.

Caption: Change the injection site for each injection.

Caption: Do not inject where the skin has pits, is thickened, or has lumps. Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.

Caption: Do not try to change your dose while injecting.

6:43-6:57

[An image of a person appears on screen, with their stomach area, buttocks, upper legs and upper arms highlighted as possible injection sites]

Narrator: Choose an injection site. Humulin R U-500 can be injected under the skin of the stomach area, in the buttocks, upper legs, or in the upper arms.

Caption: Choose an Injection Site

Caption: Stomach area

Caption: Buttocks

Caption: Upper legs

Caption: Upper arms

6:57-7:28

[An animation of a person wiping their stomach area with an alcohol swab (70% isopropyl alcohol) and then using the KwikPen to give themselves an injection in their stomach area. A timer appears on screen, counting from one to five]

Narrator: First, wipe the skin with an alcohol swab and let the injection site dry before injecting. Then, insert the needle into your skin. Push the dose knob until it stops. Hold the dose knob in and slowly count to 5. The plunger only moves a little with each injection, and you may not notice that it moves. Do not try to inject your insulin by turning the dose knob. You will not receive your insulin by turning the dose knob.

Caption: Alcohol Swab 70% Isopropyl Alcohol

7:28-7:51

[A close-up image of the pen and dose window appears showing zero]

Narrator: After counting to 5, pull the needle out of your skin. A drop of insulin at the needle tip is normal. It will not affect your dose. If you see zero in the dose window, you have received your full dose. If you do not see zero in the dose window, you did not receive your full dose. Do not redial. Insert the needle into your skin and finish your injection.

7:51-8:03

Narrator: If you still do not think you received the full amount you dialed for your injection, do not start over or repeat your injection. Monitor your blood glucose as instructed by your doctor.

Caption: If you still do not think you received your full dose, DO NOT take another dose. If you have questions, contact your doctor.

8:03-8:14

[An animation of a person holding gauze and moving it over a drop of blood on their stomach area injection site appears on screen]

Narrator: If you see blood after you take the need out of your skin, press the injection site lightly with a piece of gauze or an alcohol swab. Do not rub the area.

8:14-8:19

Narrator: Step 5: After your injection.

Caption: Step 5: After your injection

8:19-8:42

[An animation of the Humulin R U-500 KwikPen appears on screen, showing the capped needle being unscrewed and discarded, and showing the pen cap being replaced]

Narrator: Carefully replace the outer needle shield. Unscrew the capped needle and throw it away. Do not store the Pen with the needle attached to prevent leaking, blocking of the needle, and air from entering the pen. Replace the Pen cap by lining up the cap clip with the dose indicator and pushing it straight on.

8:42-8:47

Narrator: Step 6: Disposing of your pens and needles.

Caption: Step 6: Disposing of your Pens and needles

8:47-10:17

[An animation of a needle disposal container appears on screen, with a recycle symbol crossed out, indicating to NOT throw away or dispose of loose needles in household trash]

[A question mark and a hazardous waste warning image appear on screen, indicating specifications to use a household container for safe needle storage and disposal]

[The needle disposal container with the hazardous waste warning image inside it appears on screen, indicating to follow your local guidelines for safe and proper needle disposal]

Narrator: Put your used needles in an FDA-cleared sharps disposal container right away after use. Do not throw away or dispose of loose needles in your household trash. If you do not have an FDA-cleared sharps disposal container, you may use a household container that:

  • is made of a heavy-duty plastic,
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
  • stands upright and is stable during use,
  • is leak-resistant, and
  • is properly labeled to warn of hazardous waste inside the container

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: www.fda.gov/safesharpsdisposal. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container. The used Pen may be discarded in your household trash after you have removed the needle.

Caption: Place used needle in a sharps container,

Caption: or use an appropriate household container.

Caption: Follow local guidelines for proper sharps disposal.

www.fda.gov/safesharpsdisposal

10:17-10:27

Narrator: Step 7: Storing your Pen.

Caption: Step 7: Storing your pen

10:28-10:30

[The Humulin R U-500 KwikPen appears on screen, with the words “below 86°F,” and a flame image crossed out, indicating that the pen should be stored at room temperature and away from heat and light]

Narrator: The Pen you are currently using should be stored at room temperature (below 86 degrees Fahrenheit) and away from heat and light.

10:30-10:37

[An image appears with a person throwing a needle into a trash can, and on the image of a calendar tear page, the number 28 appears, indicating the pen should be thrown away after 28 days]

Narrator: After 28 days, throw the Pen away, even if it still has insulin left in it.

10:37-10:54

[The Humulin R U-500 KwikPen appears on screen, with the degrees 36°F to 46°F displayed, and a picture of a snowflake crossed out, indicating that unused pens should be stored in the refrigerator at 36 degrees Fahrenheit to 46 degrees Fahrenheit, and should not be frozen]

Narrator: Store unused Pens in the refrigerator at 36 degrees Fahrenheit to 46 degrees Fahrenheit (2 degrees Celsius to 8 degrees Celsius). Do not freeze Humulin R U-500 and do not use if it has been frozen.

Caption: Keep refrigerated

Caption: Do not freeze

10:54-11:03

[The Humulin R U-500 KwikPen appears on screen, zooms in on the pen’s label, and shows where to look for the expiration date]

Narrator: Unused Pens may be used until the expiration date printed on the label, if the Pen has been kept in the refrigerator.

Caption: Expiration

11:03-11:11

Narrator: Additionally, there is some general information to keep in mind when using your Humulin R U-500 KwikPen.

Caption: General information about the safe and effective use of your Pen

11:11-11:26

Narrator: Here are a few things you should know if you are switching to Humulin R U-500 KwikPen: Ask your doctor what your dose should be for your Pen in insulin units. Always follow your doctor’s dosing instructions.

Caption: What you should know if you are switching to Humulin® R U-500 KwikPen®: Ask your doctor what your dose should be for your Pen in insulin units. Always follow your doctor's dosing instructions.

11:26-11:38

Narrator: If you are switching from Humulin R U-500 vial (and syringe): Your Pen may measure your dose differently. Ask your doctor what your dose should be for your Pen in insulin units.

Caption: If you are switching from Humulin® R U-500 vial (and syringe): Your Pen may measure your dose differently. The markings on the dose window may not be the same as the markings on the syringe you used in the past. Ask your doctor what your dose should be for your Pen in units of insulin.

11:38-11:59

Narrator: If you are switching from another type of insulin device or pen: The Humulin R U-500 KwikPen is different from other pens. It dials 5 units with each click of the dose knob. Do not select your dose by counting clicks. You may not get enough insulin or you may get too much insulin.

Caption: If you are switching from another type of insulin device or pen: The Humulin® R U-500 KwikPen® is different from other pens. It dials 5 units with each click of the dose knob. Do not select your dose by counting clicks. You may not get enough insulin or you may get too much insulin.

11:59-12:08

[An image of a child reaching for the pen is circled. This is replaced by an image of a broken pen which is crossed out. Both images together indicate the pen should be kept out of the reach of children and should not be used if any part looks broken or damaged]

Narrator: Keep your Pen and needles out of the sight and reach of children. Do not use your Pen if any part looks broken or damaged.

Caption: Keep out of sight and reach of children.

Caption: Do not use if damaged.

12:08-12:14

[Two pens appear side-by-side on screen]

Narrator: And always carry an extra Pen in case yours is lost or damaged.

Caption: Carry an extra Pen.

12:14-12:21

[An animation of the pen displays on screen, with the pen cap twisting back and forth, indicating that the cap should be gently twisted and pulled off if there is difficulty initially removing the Pen cap]

Narrator: If you cannot remove the Pen cap, gently twist the cap back and forth, and then pull the cap straight off.

12:21-12:43

[An image of the top half of the pen appears on screen, with an arrow animation pointing down to the dose knob, indicating what to do if the needle may be blocked]

Narrator: If it is hard to push the dose knob or if the Pen is not working the right way, your needle may be blocked. Put on a new needle and prime the Pen. It may help to push the dose knob more slowly during your injection. You may have dust, food, or liquid inside the Pen. Throw the Pen away and get a new Pen.

Caption: Your needle may be blocked.

Caption: It may help to push the dose knob more slowly during your injection.

Caption: You may have dust, food, or liquid inside the Pen.

12:43-12:49

[An image appears on screen, showing an arrow pointing from the Humulin R U-500 KwikPen to an image of a syringe, and the arrow is crossed out, indicating to not transfer insulin from the Pen to a syringe]

Narrator: Do not transfer insulin from the Pen to a syringe. Severe overdose can result.

12:49-13:14

Narrator: If you have any questions or problems with your Humulin R U-500 KwikPen, contact Lilly at 1-800-LillyRx, that’s 1-800-545-5979, or call your doctor for help. For more information on Humulin R U-500 KwikPen and insulin, go to www.humulin.com.

Caption: If you have any questions or problems with your Humulin® R U-500 KwikPen®, contact Lilly at 1-800-LillyRX (1-800-545-5979) or call your doctor for help. For more information on Humulin R U-500 KwikPen and insulin, go to www.humulin.com.

13:14-21:22

[Indication and Safety Summary for Humulin R U-500 is scrolling on the screen]

Caption:

INDICATION AND SAFETY SUMMARY

Humulin® (HUE-mu-lin) R U-500 (500 units/mL) is for adults and children who need more than 200 units of insulin in a day to control high blood sugar for their diabetes mellitus. It is more concentrated than Humulin R U-100. It has 5 times as much insulin in each mL as Humulin R U-100 (100 units/mL).

It is not known if Humulin R U-500 is safe and effective when used with other insulins or when used in an insulin pump.

Warnings: Humulin R U-500 may cause serious side effects, including:

Severe low blood sugar, which can lead to seizures, unconsciousness, and death.

Severe allergic reactions. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.

Swelling of your hands and feet. Tell your doctor if you are short of breath, have swelling in your ankles, or have gained weight suddenly.

Heart failure when taking a medication from a class of drugs called thiazolidinediones (TZDs) with Humulin R U-500. This may occur in some people even if they have not had heart problems before.

Low potassium in your blood (hypokalemia). This can lead to severe breathing problems, irregular heartbeat, and death.

Do not share your Humulin R U-500 KwikPen® or U-500 syringe with anyone. Even if you have changed the needle, you or the other person can get a serious infection.

When using the Humulin R U-500 KwikPen: The Humulin R U-500 KwikPen is made to dial and deliver the correct dose of Humulin R U-500 insulin. Do not remove Humulin R U-500 from the KwikPen to inject with any syringe. This could cause severe overdose and may lead to death.

When using the Humulin R U-500 vial: There is a special syringe to measure Humulin R U-500 called the “U-500 insulin syringe.” Only use the U-500 insulin syringe to inject Humulin R U-500. If you do not use the right syringe, you may take the wrong dose of Humulin R U-500. This could cause severe overdose and may lead to death.

Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe.

Do not use Humulin R U-500 in an insulin pump or inject it into your vein.

Do not take this medicine if you have low blood sugar.

Do not change the insulin you use without talking to your doctor. Changing insulin may lead to low or high blood sugar.

Do not drive or use heavy machinery until you know how Humulin R U-500 affects you. Do not drink alcohol while using Humulin R U-500.

Common side effects

The most common side effects of Humulin R U-500 include:

Low blood sugar (hypoglycemia). Talk to your doctor about low blood sugar symptoms and treatment. Symptoms may be different for each person.

Allergic reactions, such as redness and swelling at the site where you inject.

Skin thickening or pits at the injection site (lipodystrophy).

Itching and rash.

These are not all the possible side effects of Humulin R U-500.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor about:

Any allergies you have. Your doctor can check if the medicine has ingredients that may cause a reaction.

Any medical conditions, including problems with your liver, kidney, or heart.

All the medicines you take, especially a class of drugs called thiazolidinediones, or TZDs. Be sure to include the over-the-counter medicines, vitamins, and herbal supplements you take.

How to take

Read the instructions that come with your Humulin R U-500 carefully. Take it exactly the way your doctor tells you.

Know how much Humulin R U-500 you are supposed to take. Do not change your dose unless your doctor tells you to.

Check the label of your insulin each time you use it. This will help you make sure you are using the right one.

Test your blood sugar before you take Humulin R U-500. Do not take it if your blood sugar is too low.

Do not mix Humulin R U-500 with any other insulin.

Always use a new needle when injecting Humulin R U-500. This will help you avoid infection.

Inject Humulin R U-500 under your skin. Change (rotate) where you inject your insulin with each dose. Do not inject your insulin into the exact same spot. Avoid injecting your insulin into areas where the skin has pits or lumps, or is thickened, tender, bruised, scaly, hard, scarred, or damaged. This will help reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin.

Learn more

Humulin R U-500 is a prescription medicine. For more information, call 1-800-545-5979 or go to humulin.com.

This summary provides basic information about Humulin R U-500 but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Humulin R U-500 and how to take it. Your doctor is the best person to help you decide if Humulin R U-500 is right for you.

Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. BD is a trademark of Becton Dickinson and Co.

HM CON BS 02FEB2023

PP-HM-US-2135 06/2023 ©Lilly USA, LLC 2023. All rights reserved.

21:36-21:42

[The Humulin logo appears on a white alongside text reading “How to use your U-500 KwikPen”]

Caption: How to use your U-500 KwikPen

A1C & Diabetes Treatment Options | Humulin R U-500 (2024)
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